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Article

EphA2 Is an Essential Mediator of UV Radiation–Induced Apoptosis

13 Mar 2008

Abstract excerpt

One of the physiologic consequences of excessive UV radiation (UVR) exposure is apoptosis. This critical response serves to eliminate genetically injured cells and arises, in part, from activation of DNA damage and p53 signaling. Other contributory pathways, however, likely exist but have not been fully characterized. In a recent global screen of UVR response genes in melanocytes, we identified the receptor...

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PMID: 18339848
DOI: 10.1158/0008-5472.can-07-2372

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