Article
Cell cycle dependent telomere regulation by telomerase in human bone marrow mesenchymal stem cells.
Biochemical and biophysical research communications - 16 May 2008
Zhao Yan-Min, Li Jing-Yuan, Lan Jian-Ping, Lai Xiao-Yu, Luo Yi, Sun Jie, Yu Jian, Zhu Yuan-Yuan, Zeng Fen-Fang, Zhou Qian, Huang He
Abstract excerpt
Human bone marrow mesenchymal stem cells (hMSCs) are a promising source for clinical stem cell transplantation. However, telomere regulation mechanisms, as one of the possible major mechanisms by which hMSCs sustain their stem cell characteristics, remain unknown. We isolated hMSCs by plastic adhesion and characterized these cells by morphology, immune phenotype and differentiation capacity. Telomerase was found...
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