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Article

Fetal ethanol exposure activates protein kinase a and impairs<i>Shh</i>expression in prechordal mesendoderm cells in the pathogenesis of holoprosencephaly

12 Mar 2008

Abstract excerpt

BACKGROUND: In humans, fetal ethanol exposure can cause holoprosencephaly (HPE), one of the most common birth defects that is characterized by brain, facial, and oral abnormalities. However, the pathogenesis of HPE is not clear. In the present study, we investigated the teratogenic mechanism of ethanol-induced brain and facial malformations in mice. METHODS: Pregnant C57BL/6J mice were administered ethanol on E7...

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PMID: 18338389
DOI: 10.1002/bdra.20447

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