Rapid determination of nucleotide content and its application to the study of genome structure.

doi:10.1093/nar/19.19.5181

Back to search

Article

Rapid determination of nucleotide content and its application to the study of genome structure.

Nucleic acids research - 11 Oct 1991

Krane D E, Hartl D L, Ochman H

Abstract excerpt

We have developed a sensitive, reliable and accurate procedure for estimating the base composition of small samples of DNAs. This method has been applied to the analysis of genomic DNAs from several sources including large regions of human DNA cloned as yeast artificial chromosomes. To determine...

Topics

Bacteria
Bacteriophage lambda
Base Composition
Chromatography, Thin Layer
Cystic Fibrosis
DNA
Deoxyribonucleotides
Genetic Variation
Genome
Genome, Human
Humans
Hypoxanthine Phosphoribosyltransferase
Yeasts

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.