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Article

p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein.

Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2008

Chen Guifang, Guo Xuemin, Lv Fengxiang, Xu Yihui, Gao Guangxia

Abstract excerpt

The zinc-finger antiviral protein (ZAP) specifically inhibits the replication of many viruses by preventing the accumulation of viral mRNAs in the cytoplasm. ZAP directly binds to the viral mRNAs and recruits the RNA exosome to degrade the target RNA. In the present study, we identified the p72 DEAD box RNA helicase, but not the highly similar RNA helicase p68, as a ZAP-interacting protein. The binding domain of...

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Identifiers

PMID: 18334637
DOI: 10.1073/pnas.0712276105
PMCID: PMC2393818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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