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Article

14-3-3 CSF levels in sporadic Creutzfeldt-Jakob disease differ across molecular subtypes.

Neurobiology of aging - 1 Nov 2009

Gmitterová K, Heinemann U, Bodemer M, Krasnianski A, Meissner B, Kretzschmar H A, Zerr I

Abstract excerpt

BACKGROUND: The 14-3-3 protein is a physiological cellular protein expressed in various tissues, and its release to CSF reflects extensive neuronal damage as in Creutzfeldt-Jakob disease (CJD), but also in other neurological diseases. 14-3-3 protein in CSF in the proper clinical context is a reliable diagnostic tool for sporadic CJD. However, the sensitivity varies across molecular CJD subtypes. OBJECTIVE: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18328602
DOI: 10.1016/j.neurobiolaging.2008.01.007

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PRNP

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