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Article

Basal-like subtype of breast cancer: a review of its unique characteristics and their clinical significance.

Breast cancer (Tokyo, Japan) - 1 Jan 2008

Kobayashi Shunzo

Abstract excerpt

Subtyping of breast cancers by means of DNA microarray analyses has given rise to the new concept of the basal-like subtype; this subtype is in effect the equivalent of so-called "triple-negative" breast cancer. Basal-like breast cancer has aggressive characteristics, such as high histological grade, mutation of the TP53 gene, and negative hormone receptors. It tends to occur in relatively young women and is...

Topics

Breast Neoplasms
ErbB Receptors
Female
Genes, BRCA1
Humans
Mutation
Neoplasms, Basal Cell
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18311481
DOI: 10.1007/s12282-008-0034-3

Genes

BRCA1
EGFR

Provenance

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