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Article

Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Feb 2008

Solowska Joanna M, Morfini Gerardo, Falnikar Aditi, Himes B Timothy, Brady Scott T, Huang Dongyang, Baas Peter W

Abstract excerpt

Spastin and P60-katanin are two distinct microtubule-severing proteins. Autosomal dominant mutations in the SPG4 locus corresponding to spastin are the most common cause of hereditary spastic paraplegia (HSP), a neurodegenerative disease that afflicts the adult corticospinal tracts. Here we sought to evaluate whether SPG4-based HSP is best understood as a "loss-of-function" disease. Using various rat tissues, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18305248
DOI: 10.1523/JNEUROSCI.3159-07.2008
PMCID: PMC2693295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia.PMID 18305248Read ↗

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