Article
Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule.
BMC microbiology - 25 Feb 2008
Schouls Leo, van der Heide Han, Witteveen Sandra, Zomer Bert, van der Ende Arie, Burger Marina, Schot Corrie
Abstract excerpt
BACKGROUND: Despite nearly complete vaccine coverage, a small number of fully vaccinated children in the Netherlands have experienced invasive disease caused by Haemophilus influenzae serotype b (Hib). This increase started in 2002, nine years after the introduction of nationwide vaccination in the Netherlands. The capsular polysaccharide of Hib is used as a conjugate vaccine to protect against Hib disease. To...
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