Article
The effect of genetic determinants of low density lipoprotein levels on lipoprotein (a).
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Apr 1991
Hegele R A, Sutherland S, Robertson M, Wu L, Emi M, Hopkins P N, Williams R R, Lalouel J M
Abstract excerpt
Levels of Lipoprotein(a) [Lp(a)] correlate directly with atherosclerosis risk. The Lp(a) particle is physically and chemically similar to low density lipoprotein (LDL), the main difference being the presence of apolipoprotein(a) [apo(a)] bonded to the apoB-100 moiety of LDL. Genetic variation of apo(a) primarily determines Lp(a) phenotype. However, other genetic factors may also have a role in determining Lp(a)...
Topics
- Apolipoprotein B-100
- Apolipoproteins A
- Apolipoproteins B
- Base Sequence
- Binding Sites
- Cholesterol, HDL
- DNA
- Genetic Variation
- Humans
- Hyperlipoproteinemia Type II
- Hypobetalipoproteinemias