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Article

Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii.

PLoS pathogens - 8 Feb 2008

Gubbels Marc-Jan, Lehmann Margaret, Muthalagi Mani, Jerome Maria E, Brooks Carrie F, Szatanek Tomasz, Flynn Jayme, Parrot Ben, Radke Josh, Striepen Boris, White Michael W

Abstract excerpt

Apicomplexa are obligate intracellular pathogens that have fine-tuned their proliferative strategies to match a large variety of host cells. A critical aspect of this adaptation is a flexible cell cycle that remains poorly understood at the mechanistic level. Here we describe a forward genetic dissection of the apicomplexan cell cycle using the Toxoplasma model. By high-throughput screening, we have isolated 165...

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Identifiers

PMID: 18282098
DOI: 10.1371/journal.ppat.0040036
PMCID: PMC2242837

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