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Article

I(Kr) channel blockade to unmask occult congenital long QT syndrome.

Heart rhythm - 1 Jan 2008

Jeyaraj Darwin, Abernethy Denise P, Natarajan Rupa N, Dettmer Mary M, Dikshteyn Maria, Meredith Diana M, Patel Kevin, Allareddy Raghavendra R, Lewis Steven A, Kaufman Elizabeth S

Abstract excerpt

BACKGROUND: Patients with genetic evidence of long QT syndromes type 1 and 2 (LQT1, associated with impaired outward potassium current I(Ks); and LQT2, associated with impaired outward potassium current I(Kr)) may have normal baseline QT intervals (phenotype/genotype discordance) and elude clinical detection. Beta-adrenergic stimulation may unmask occult LQT1, but no maneuver has consistently unmasked the LQT2...

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Identifiers

PMID: 18273958
DOI: 10.1016/j.hrthm.2007.08.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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