Article
Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes.
The Journal of general virology - 1 Mar 2008
Runkler Nicole, Dietzel Erik, Moll Markus, Klenk Hans-Dieter, Maisner Andrea
Abstract excerpt
We previously demonstrated the presence of tyrosine-dependent motifs for specific sorting of two measles virus (MV) glycoproteins, H and F, to the basolateral surface in polarized epithelial cells. Targeted expression of the glycoproteins was found to be required for virus spread in epithelia via cell-to-cell fusion in vitro and in vivo. In the present study, recombinant MVs (rMVs) with substitutions of the...
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