[Cross-talk between nuclear factor-kappaB and P53 signal pathway in keratinocytes after ultraviolet B irradiation].

Abstract excerpt

OBJECTIVE: To investigate the cross-talk between nuclear factor kappaB (NF-kappaB) and P53 signal pathways in human epidermal keratinocytes (NHEKs) after ultraviolet B (UVB) irradiation. METHODS: Normal NHEKs harboring wild p53 gene and immortal human keratinocytes of the line HaCaT harboring mutant p53 gene were cultured at 37 degrees C in an atmosphere containing 5% CO(2) and then underwent irradiation of UVB...

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