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Article

Transforming growth factor-beta enhances the ultraviolet-mediated stress response in p53-/- keratinocytes.

International journal of oncology - 1 Oct 1998

Merryman J I, Neilsen N, Stanton D D

Abstract excerpt

Skin cancer is the most common tumor type in Caucasians, with an incidence that approaches the lifetime risk for all other cancer subtypes combined. The most common predisposing factor in the development of non-melanoma skin cancer is exposure to ultraviolet (UV) radiation in sun-light. UV radiation activates c-Jun amino-terminal kinases (JNK); this kinase pathway is involved in UV-mediated apoptosis and...

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PMID: 9735409
DOI: 10.3892/ijo.13.4.781

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transforming growth factor-beta enhances the ultraviolet-mediated stress response in p53-/- keratinocytes.PMID 9735409Read ↗

Mutational status of the p53 gene modulates the basal level of jun N-terminal kinase and its inducibility by ultraviolet irradiation in A1-5 rat fibroblasts.Semantic proximity Read ↗

Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for CarcinogenesisSemantic proximity Read ↗

Modulation of keratin 1, 10 and involucrin expression as part of the complex response of the human keratinocyte cell line HaCaT to ultraviolet radiationSemantic proximity Read ↗

In situ demonstration of phosphorylated c-jun and p38 MAP kinase in epidermal keratinocytes following ultraviolet B irradiation of human skinSemantic proximity Read ↗

Differential Activation of Signaling Pathways by UVA and UVB Radiation in Normal Human Epidermal Keratinocytes†Semantic proximity Read ↗

Differential Stimulation of ERK and JNK Activities by Ultraviolet B Irradiation and Epidermal Growth Factor in Human KeratinocytesSemantic proximity Read ↗

Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-β1 signaling pathwaySemantic proximity Read ↗

Anti-Apoptotic NF-κB and “Gain of Function” mutp53 in Concert Act Pro-Apoptotic in Response to UVB+IL-1 via Enhanced TNF ProductionSemantic proximity Read ↗

Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor.Semantic proximity Read ↗

Ultraviolet Irradiation Alters Transforming Growth Factor β/Smad Pathway in Human Skin In VivoSemantic proximity Read ↗

UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53Semantic proximity Read ↗

UV Radiation Activates Toll-Like Receptor 9 Expression in Primary Human Keratinocytes, an Event Inhibited by Human Papillomavirus 38 E6 and E7 OncoproteinsSemantic proximity Read ↗

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