Article
Transforming growth factor-beta enhances the ultraviolet-mediated stress response in p53-/- keratinocytes.
International journal of oncology - 1 Oct 1998
Merryman J I, Neilsen N, Stanton D D
Abstract excerpt
Skin cancer is the most common tumor type in Caucasians, with an incidence that approaches the lifetime risk for all other cancer subtypes combined. The most common predisposing factor in the development of non-melanoma skin cancer is exposure to ultraviolet (UV) radiation in sun-light. UV radiat...
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Enzyme Activation
- Gene Expression
- Genes, p53
- Humans
- JNK Mitogen-Activated Protein Kinases
- Keratinocytes
- Mitogen-Activated Protein Kinases
- Mutation
- Myelin Basic Protein
- Recombinant Fusion Proteins
- Time Factors
- Transforming Growth Factor beta
- Ultraviolet Rays