Article
Cryoablative response of prostate cancer cells is influenced by androgen receptor expression.
BJU international - 1 May 2008
Klossner Daniel P, Baust John M, VanBuskirk Robert G, Gage Andrew A, Baust John G
Abstract excerpt
OBJECTIVE: To investigate in prostate cancer cells the consequences of androgen-insensitivity (AI) development on the cellular and molecular responses to freezing, as a challenge in prostate cancer treatment occurs when the androgen-sensitive (AS) phenotype switches to an AI phenotype, the latter of which is often refractory to many therapies. MATERIALS AND METHODS: PC-3 (AI) and LNCaP (AS) were each genetically...
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