Article
Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis.
PloS one - 6 Feb 2008
Martinelli Nicola, Trabetti Elisabetta, Pinotti Mirko, Olivieri Oliviero, Sandri Marco, Friso Simonetta, Pizzolo Francesca, Bozzini Claudia, Caruso Pier Paolo, Cavallari Ugo, Cheng Suzanne, Pignatti Pier Franco, Bernardi Francesco, Corrocher Roberto, Girelli Domenico
Abstract excerpt
BACKGROUND: Relative little attention has been devoted until now to the combined effects of gene polymorphisms of the hemostatic pathway as risk factors for Myocardial Infarction (MI), the main thrombotic complication of Coronary Artery Disease (CAD). The aim of this study was to evaluate the combined effect of ten common prothrombotic polymorphisms as a determinant of MI. METHODOLOGY/PRINCIPAL FINDINGS: We...
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