Article
Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2008
Klimek Virginia M, Fircanis Sophia, Maslak Peter, Guernah Ilhem, Baum Michael, Wu Nian, Panageas Katherine, Wright John J, Pandolfi Pier Paolo, Nimer Stephen D
Abstract excerpt
PURPOSE: Epigenetic modulation of gene expression plays an important role in cancer, including leukemia. Furthermore, histone deacetylase inhibitors may induce the reexpression or repression of genes critical for normal hematopoiesis. The purpose of this study was to evaluate the toxicity, pharmacokinetic profile, and selected pharmacodynamic properties of the histone deacetylase inhibitor depsipeptide in...
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