Article
Neurological disorders due to mutations of the mitochondrial genome.
Neuromuscular disorders : NMD - 1 Jan 1991
Zeviani M, DiDonato S
Abstract excerpt
The rapidly expanding list of human diseases due to lesions of mitochondrial DNA includes myopathies, encephalopathies, cardiomyopathies, or various combinations of the latter, leading to multisystem disorders, which can also affect visceral organs. Five maternally inherited diseases, mainly affecting muscle and brain, are due to point mutations of mitochondrial genes encoding either respiratory chain...
Topics
- DNA, Mitochondrial
- Genome, Human
- Humans
- Mutation
- Nervous System Diseases