Article
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
Infection and immunity - 1 Apr 2008
Hu Yanmin, Henderson Brian, Lund Peter A, Tormay Peter, Ahmed M Tabish, Gurcha Sudagar S, Besra Gurdyal S, Coates Anthony R M
Abstract excerpt
The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are essential for cell survival. A mutant lacking Cpn60.1 was indistinguishable from the wild-type organism in plate and broth culture and within murine macrophages, although it showed increased sensitivity to high...
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