Article
Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation.
Basic & clinical pharmacology & toxicology - 1 Feb 2008
Kishi Reiko, Sata Fumihiro, Yoshioka Eiji, Ban Susumu, Sasaki Seiko, Konishi Kanae, Washino Noriaki
Abstract excerpt
There is increasing evidence from epidemiological studies that genetic susceptibilities may modify the teratogenic effects of toxic chemicals. However, in contrast to tobacco smoke, few epidemiological studies have addressed environmental chemicals, such as polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in regard to genetic susceptibility. Recent studies, including...
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