Article
ERas oncogene expression and epigenetic regulation by histone acetylation in human cancer cells.
Anticancer research - 1 Jan 2000
Yasuda Koichi, Yashiro Masakazu, Sawada Tetsuji, Ohira Masaichi, Hirakawa Kosei
Abstract excerpt
The ERas oncogene is a recently identified gene that supports the tumorigenic growth of embryonic stem (ES) cells by producing a constitutively active Ras protein. However the expression of ERas in cancer cells remains unclear. In this study, ERas mRNA expression was examined in 20 human cancer cell lines and 5 normal cell lines. ERas mRNA was found in 4 out of 7 colorectal carcinomas, 2 out of 6 pancreatic...
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