Article
Enzymatic activity of circulating proteasomes correlates with clinical behavior in patients with chronic lymphocytic leukemia.
Cancer - 15 Mar 2008
Ma Wanlong, Kantarjian Hagop, O'Brien Susan, Jilani Iman, Zhang Xi, Estrov Zeev, Ferrajoli Alessandra, Keating Michael, Giles Francis, Albitar Maher
Abstract excerpt
BACKGROUND: The ubiquitin-proteasome pathway has been implicated in the pathogenesis of many hematologic malignancies. METHODS: The authors measured proteasome peptidase activity levels in plasma samples from 225 patients with chronic lymphocytic leukemia (CLL) and correlated the results with clinical behavior. By using fluorogenic kinetic assays, the enzymatic activity levels of 3 proteasomes were measured:...
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