Article
Association and linkage disequilibrium analyses of APOE polymorphisms in atherosclerosis.
Disease markers - 1 Jan 2008
Artieda Marta, Gañán Alberto, Cenarro Ana, García-Otín Angel Luis, Jericó Ivonne, Civeira Fernando, Pocoví Miguel
Abstract excerpt
BACKGROUND: Apolipoprotein E (apo E) plays a major role in lipid metabolism, and its genetic variations have been associated with cardiovascular risk. The objective of this study was to investigate the influence of the APOE promoter (-491 A/T, -427 T/C and -219 G/T) and coding region (APOE epsilon2/epsilon3/epsilon4) polymorphisms in atherosclerosis disease by association and linkage disequilibrium analyses....
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