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Article

Congenital chloride-losing diarrhea causing mutations in the STAS domain result in misfolding and mistrafficking of SLC26A3.

The Journal of biological chemistry - 28 Mar 2008

Dorwart Michael R, Shcheynikov Nikolay, Baker Jennifer M R, Forman-Kay Julie D, Muallem Shmuel, Thomas Philip J

Abstract excerpt

Congenital chloride-losing diarrhea (CLD) is a genetic disorder causing watery stool and dehydration. Mutations in SLC26A3 (solute carrier 26 family member 3), which functions as a coupled Cl(-)/HCO(3)(-) exchanger, cause CLD. SLC26A3 is a membrane protein predicted to contain 12 transmembrane-spanning alpha-helices and a C-terminal STAS (sulfate transporters and anti-sigma-factor) domain homologous to the...

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Identifiers

PMID: 18216024
DOI: 10.1074/jbc.M704328200
PMCID: PMC2417183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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