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Article

A Rapid and Quantitative Assay for Measuring Neighboring Gene Activation by Vector Proviruses

22 Jan 2008

Abstract excerpt

A simple, quantitative assay for measuring the oncogenic potential of integrating vectors is needed in order to improve vector design and safety. In this study, we have developed a transient plasmid-based assay to measure the activation of a reporter gene by an adjacent vector provirus. Plasmid pACT contains a luciferase cassette driven by a minimal, enhancerless promoter, into which vector proviruses are...

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PMID: 18209733
DOI: 10.1038/sj.mt.6300398

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