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Article

External suppression causes the low expression of the Cosmc gene in IgA nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2008

Qin Wei, Zhong Xiang, Fan Jun Ming, Zhang Ying Juan, Liu Xian Rong, Ma Xing Yi

Abstract excerpt

OBJECTIVE: IgA(1) aberrant O-glycosylation is one of the main pathogeneses of IgA nephropathy (IgAN), and the core I beta3-Gal-T-specific molecular chaperone (Cosmc) mRNA expression of IgAN patients was significantly decreased. This study tried to clarify whether the down-regulation was a result...

Read the complete abstract on PubMed

Topics

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Share to B-Lymphocytes
Share to Down-Regulation
Share to Glomerulonephritis, IGA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Immunoglobulin A

Share to Lipopolysaccharides

Share to Molecular Chaperones

Share to Mutation, Missense

Source

Identifiers

PMID: 18202089
DOI: 10.1093/ndt/gfm781

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18202089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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