Article
TGF-beta1 gene polymorphisms and peritoneal equilibration test results in CAPD patients.
Renal failure - 1 Jan 2008
Ebinç Fatma Ayerden, Derici Ulver, Gönen Sevim, Reis Kadriye Altok, Erten Yasemin, Bali Musa, Sindel Sükrü, Arinsoy Turgay
Abstract excerpt
Transforming growth factor-beta1 (TGF-beta1) stimulates the expression of collagen mRNA in cultured human peritoneal mesangial cells, which may predispose them to developing peritoneal fibrosis. Polymorphisms in the signal sequence genetically may be responsible for increased TGF-beta1 production (i.e., a substitution at amino acid position 10 and 25, +869 Leu(10)-Pro and +915 Arg(25)-Pro, respectively). The aim...
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