Article
Within-family outliers: segregating alleles or environmental effects? A linkage analysis of height from 5815 sibling pairs.
European journal of human genetics : EJHG - 1 Apr 2008
Benyamin Beben, Perola Markus, Cornes Belinda K, Madden Pamela Af, Palotie Aarno, Nyholt Dale R, Montgomery Grant W, Peltonen Leena, Martin Nicholas G, Visscher Peter M
Abstract excerpt
Most information in linkage analysis for quantitative traits comes from pairs of relatives that are phenotypically most discordant or concordant. Confounding this, within-family outliers from non-genetic causes may create false positives and negatives. We investigated the influence of within-family outliers empirically, using one of the largest genome-wide linkage scans for height. The subjects were drawn from...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.