Article
Case-control and within-family tests for an association between conduct disorder and DAT1.
Psychiatric genetics - 1 Feb 2008
Schulz-Heik R Jay, Maentz Sarah K, Rhee Soo Hyun, Gelhorn Heather L, Young Susan E, Timberlake David S, Smolen Andrew, Stetler Gary L, Sakai Joseph T, Crowley Thomas J
Abstract excerpt
BACKGROUND: Conduct disorder (CD) is characterized by a persistent pattern of violating age-appropriate norms and the rights of others, and is one of the most frequently diagnosed disorders among children. CD is moderately heritable, but we know of no reliable associations with specific genes. Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be...
Topics
- Adolescent
- Adult
- Case-Control Studies
- Conduct Disorder
- Dopamine Plasma Membrane Transport Proteins
- Family
- Genetic Predisposition to Disease
- Humans
- Linkage Disequilibrium
- Prevalence
- Substance-Related Disorders
- United States
