Article
Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses.
Nature medicine - 1 Feb 2008
Lasaro Marcio O, Tatsis Nia, Hensley Scott E, Whitbeck J Charles, Lin Shih-Wen, Rux John J, Wherry E John, Cohen Gary H, Eisenberg Roselyn J, Ertl Hildegund C
Abstract excerpt
Interactions between the herpesvirus entry mediator (HVEM) and the B- and T-lymphocyte attenuator (BTLA) inhibit B and T cell activation. HVEM-BTLA interactions are blocked by herpes simplex virus (HSV) glycoprotein D (gD) through binding of its N-terminal domain to the BTLA binding site of HVEM. In this study, we inserted viral antigens into the C-terminal domain of gD and expressed these antigens with plasmid...
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