Article
[Biochemical basis of varying nystatin resistance of Saccharomyces cerevisiae and Candida maltosa mutants].
Mikrobiologiia - 1 Jan 2000
Ogorodnikova T E, Durasova E N, Sinitskaia N A, Orlov A I, Mikhailova N P, V'iunov K A
Abstract excerpt
Six groups of nystatin resistant mutants of C. maltosa and of haploid and diploid Saccharomyces cerevisiae strains were obtained with the help of genetic and biochemical analysis. It has been shown that every group of the mutants was characterized by a specific level of resistance to nystatin. The dependence of the resistance level upon sterol content has been established. It has been shown that the more the...
Topics
- Candida
- Drug Resistance, Microbial
- Molecular Structure
- Mutation
- Nystatin
- Saccharomyces cerevisiae
- Sterols
- Structure-Activity Relationship