Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture.

doi:10.1016/j.ajhg.2007.09.012

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Article

Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture.

American journal of human genetics - 1 Jan 2008

Enattah Nabil Sabri, Jensen Tine G K, Nielsen Mette, Lewinski Rikke, Kuokkanen Mikko, Rasinpera Heli, El-Shanti Hatem, Seo Jeong Kee, Alifrangis Michael, Khalil Insaf F, Natah Abdrazak, Ali Ahmed, Natah Sirajedin, Comas David, Mehdi S Qasim, Groop Leif, Vestergaard Else Marie, Imtiaz Faiqa, Rashed Mohamed S, Meyer Brian, Troelsen Jesper, Peltonen Leena

Abstract excerpt

The T(-13910) variant located in the enhancer element of the lactase (LCT) gene correlates perfectly with lactase persistence (LP) in Eurasian populations whereas the variant is almost nonexistent among Sub-Saharan African populations, showing high prevalence of LP. Here, we report identification of two new mutations among Saudis, also known for the high prevalence of LP. We confirmed the absence of the European...

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Identifiers

PMID: 18179885
DOI: 10.1016/j.ajhg.2007.09.012
PMCID: PMC2253962

Genes

LCT
MCM6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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