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A Macrophage Gene Expression Signature Defines a Field Effect in the Lung Tumor Microenvironment

1 Jan 2008

Abstract excerpt

One area of intensive investigation is to understand complex cellular and signaling interactions in the tumor microenvironment. Using a novel, although straightforward, microarray approach, we defined a gene expression signature from the lung tumor microenvironment in the murine A/J-urethane model of human lung adenocarcinoma. The tumor microenvironment is reflected by the composition of the cell types present...

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PMID: 18172294
DOI: 10.1158/0008-5472.can-07-0988

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