Article
Pyrophosphorolysis detects B-RAF mutations in primary uveal melanoma.
Investigative ophthalmology & visual science - 1 Jan 2008
Maat Willem, Kilic Emine, Luyten Gré P M, de Klein Annelies, Jager Martine J, Gruis Nelleke A, Van der Velden Pieter A
Abstract excerpt
PURPOSE: Mutations in the genes that control cell proliferation in cutaneous melanoma are generally uncommon in uveal melanoma. Despite the absence of known activating mutations, the RAF-MEK-ERK, or mitogen-activated protein kinase (MAPK), pathway is usually activated in uveal melanoma. An assay...
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