Article
Transfusion support for a patient with McLeod phenotype without chronic granulomatous disease and with antibodies to Kx and Km.
Vox sanguinis - 1 Apr 2008
Bansal I, Jeon H-R, Hui S R, Calhoun B W, Manning D W, Kelly T J, Lee S, Baron B W
Abstract excerpt
BACKGROUND AND OBJECTIVES: Kell antigens are encoded by the KEL gene on the long arm of chromosome 7. Kx antigen is encoded by the XK gene on the short arm of the X chromosome. Kell and Kx proteins in the red cell membrane are covalently linked by a disulphide bond. The McLeod phenotype is characterized by weakened expression of antigens in the Kell blood group system, absence of Km and Kx antigens, and...
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