Article
Hematopoietic Cell Transplantation in a Patient With X-Linked Chronic Granulomatous Disease With McLeod Phenotype.
Pediatric transplantation - 1 May 2025
Fujimori Kentaro, Shimizu Soichiro, Ishikawa Takashi, Gocho Yoshihiro, Sakaguchi Hirotoshi, Uchiyama Toru, Nakabayashi Kazuhiko, Tomizawa Daisuke, Onodera Masafumi, Matsumoto Kimikazu, Kawai Toshinao, Iguchi Akihiro
Abstract excerpt
BACKGROUND: X-linked chronic granulomatous disease (X-CGD) may be associated with McLeod syndrome (MLS) as a contiguous gene deletion syndrome. MLS is characterized by the loss of XK protein along with Kx antigen on red blood cell (RBC) surfaces and late-onset neurocognitive symptoms. RBCs in healthy donors express XK protein and related Kx antigen on the surface; therefore, transfusion from random donors to...
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