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Article

Genetic investigation of four meiotic genes in women with premature ovarian failure.

European journal of endocrinology - 1 Jan 2008

Mandon-Pépin Béatrice, Touraine Philippe, Kuttenn Frédérique, Derbois Céline, Rouxel Agnes, Matsuda Fumihiko, Nicolas Alain, Cotinot Corinne, Fellous Marc

Abstract excerpt

OBJECTIVE: The goal of this study was to determine whether mutations of meiotic genes, such as disrupted meiotic cDNA (DMC1), MutS homolog (MSH4), MSH5, and S. cerevisiae homolog (SPO11), were associated with premature ovarian failure (POF). DESIGN: Case-control study. METHODS: Blood sampling, karyotype, hormonal dosage, ultrasound, and ovarian biopsy were carried out on most patients. However, the main outcome...

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Source

Identifiers

PMID: 18166824
DOI: 10.1530/EJE-07-0400

Genes

DMC1
MSH5
MSH4
SPO11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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