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Article

RANTES Promoter Gene Polymorphisms and Susceptibility to Severe Respiratory Syncytial Virus-Induced Bronchiolitis

1 Jan 2008

Abstract excerpt

BACKGROUND: Severe respiratory syncytial virus (RSV) infection is characterized by enhanced chemokine activity. Several studies have linked increased regulated on activation, normal T cell expressed and secreted (RANTES) expression with severe RSV disease. Three single nucleotide polymorphisms, -28C/G, -403G/A, and In1.1T/C in the RANTES gene, have been correlated with the gene's transcriptional activity. In the...

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PMID: 18162936
DOI: 10.1097/inf.0b013e31814d4e42

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