Article
Antiproliferative, antioxidant, and antimutagenic activities of flavonoid-enriched extracts from (Tunisian) Rhamnus alaternus L.: combination with the phytochemical composition.
Drug and chemical toxicology - 1 Jan 2008
Ammar Rebai Ben, Kilani Soumaya, Bouhlel Ines, Ezzi Lobna, Skandrani Ines, Boubaker Jihed, Sghaier Mohamed Ben, Naffeti Aicha, Mahmoud Amor, Chekir-Ghedira Leila, Ghedira Kamel
Abstract excerpt
A pronounced antiproliferative effect on human leukemia K562 cells was shown with flavonoid-enriched extracts from Rhamnus alaternus roots and leaves, with, respectively, IC(50) values of 165 and 210.73 microg/mL. High DPPH radical-scavenging activity (7.21 and 18.84 microg/mL, respectively) and antioxidative effects using the xanthine oxidase assay (IC(50) values of 83.33 and 103.96 microg/mL, respectively) were...
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