Article
Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier.
Pathology oncology research : POR - 1 Jan 2007
Grant Stephen G, Das Rubina, Cerceo Christina M, Rubinstein Wendy S, Latimer Jean J
Abstract excerpt
Homozygous loss of activity at the breast cancerpredisposing genes BRCA1 and BRCA2 (FANCD1) confers increased susceptibility to DNA double strand breaks, but this genotype occurs only in the tumor itself, following loss of heterozygosity at one of these loci. Thus, if these genes play a role in tumor etiology as opposed to tumor progression, they must manifest a heterozygous phenotype at the cellular level. To...
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