Article
Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicity.
Toxicology and applied pharmacology - 1 Mar 2008
Guindon Katherine A, Foley Julie F, Maronpot Robert R, Massey Thomas E
Abstract excerpt
The carcinogenic mycotoxin aflatoxin B(1) (AFB(1)) induces 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in mouse lung, an effect that can be prevented by treatment with polyethylene glycol-conjugated catalase (PEG-CAT). G-->T transversion mutation in K-ras, an early event in AFB(1)-induced mouse lung carcinogenesis, is thought to result from AFB(1)-8,9-exo-epoxide binding to DNA to form AFB(1)-N(7)-guanine, but...
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