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Article

Inhibition of placental P‐glycoprotein: impact on indinavir transfer to the foetus

18 Dec 2007

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: We have shown previously using the dually perfused isolated human placenta model that the maternal to foetal transfer of the antiviral protease inhibitor drug indinavir is substantially lower than the transfer in the opposite direction. This finding is not consistent with passive diffusion and indicates that a carrier-mediated mechanism is involved in retarding the...

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PMID: 18093255
DOI: 10.1111/j.1365-2125.2007.03067.x

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