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The role of sperm proteasomes during sperm aster formation and early zygote development: implications for fertilization failure in humans

19 Dec 2007

Abstract excerpt

BACKGROUND Sperm aster organization during bovine and human fertilization requires a paternally-derived centriole that must first disengage from the sperm tail connecting-piece. We investigated the participation of the 26S proteasome in this process. METHODS Proteasome localization and enzymatic activity were studied in normal and pathological human spermatozoa by immunocytochemistry and enzyme-substrate assays....

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PMID: 18089554
DOI: 10.1093/humrep/dem385

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