Maturation of <i>Streptococcus pneumoniae</i> lipoproteins by a type II signal peptidase is required for ABC transporter function and full virulence

Abstract excerpt

Cell surface lipoproteins are important for the full virulence of several bacterial pathogens, including Streptococcus pneumoniae. Processing of prolipoproteins seems to be conserved among different bacterial species, and requires type II signal peptidase (Lsp) mediated cleavage of the N-terminal signal peptide to form the mature lipoprotein. Lsp has been suggested as a target for new antibiotic therapies, but at...

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