Article
Alanine variant of the Pro12Ala polymorphism of the PPARgamma gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes.
Diabetes research and clinical practice - 1 Apr 2008
Malecki Maciej T, Cyganek Katarzyna, Mirkiewicz-Sieradzka Barbara, Wolkow Pawel P, Wanic Krzysztof, Skupien Jan, Solnica Bogdan, Sieradzki Jacek
Abstract excerpt
OBJECTIVE: Molecular background of diabetic retinopathy (DR) remains unknown. An interesting group of candidate genes encode proteins involved in insulin resistance. AIM: To search for association between the PPARgamma, calpain 10, PTPN1 genes and DR in type 2 diabetes mellitus (T2DM). METHODS: We examined 238 T2DM subjects without DR (NDR) and 121 with DR (mean diabetes duration: 9.1+/-6.8 and 15.1+/-7.7,...
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