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Article

Upregulation of Beclin 1 in the ischemic penumbra

16 Feb 2008

Abstract excerpt

Here we discuss the probable role of autophagy in cerebral ischemia based on our own recent data and the literature. We examined the protein level of Beclin 1 (Bcl-2 interacting protein) and microtubule-associated protein 1 light chain 3 (LC3) which were previously found to promote autophagy. We found a dramatic elevation in Beclin 1 levels and LC3 in the penumbra of rats challenged by cerebral ischemia. We found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18075295
DOI: 10.4161/auto.5339

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