Cytogenetic study of spontaneous abortions using semi‐direct analysis of chorionic villi samples detects the broadest spectrum of chromosome abnormalities

Abstract excerpt

Conventional tissue culturing and karyotyping of spontaneous abortions has limitations such as culture failure, external contamination and selective growth of maternal cells. Molecular cytogenetic techniques such as FISH, QF-PCR, and CGH allow diagnosis on uncultured cells but are also limited as to the spectrum of cytogenetic abnormalities detected. We describe the cytogenetic findings in a series of 116 first...

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