Article
Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomes.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Oct 2007
Veenstra David L, Harris Julie, Gibson Ronald L, Rosenfeld Margaret, Burke Wylie, Watts Carolyn
Abstract excerpt
BACKGROUND: Aminoglycosides are commonly used in cystic fibrosis patients to treat Pseudomonas aeruginosa respiratory infections. Aminoglycoside-induced hearing loss may occur in 1%-15% of patients with cystic fibrosis, ranging from mild to severe. Recently, a genetic test to identify patients wi...
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