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[Mutations in tumor suppressor gene NBS1 in adult patients with malignancies].

Casopis lekaru ceskych - 1 Jan 2006

Seemanová E, Hoch J, Herzogová J, Kawaciuk I, Janda J, Kohoutová M, Seeman P, Varon R, Sperling K

Abstract excerpt

BACKGROUND: Mutations 657del5 and R215W in exon 6 of tumor suppressor gene NBS I are found in 1% Slavic populations. Increased occurrence of cancer was repeatedly reported in adult relatives of patients with Nijmegen breakage syndrome. Among children with oncological problematic, nonsignificantly increased frequency of NBS1 heterozygotes was found, which seems not to play any important role in cancerogenesis in...

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PMID: 16634478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Mutations in tumor suppressor gene NBS1 in adult patients with malignancies].PMID 16634478Read ↗

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Heterozygous carriers of the I171V mutation of the NBS1 gene have a significantly increased risk of solid malignant tumours.Semantic proximity Read ↗

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Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland.Semantic proximity Read ↗

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Clinical course and therapeutic implications for lymphoid malignancies in Nijmegen breakage syndrome.Semantic proximity Read ↗

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